A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction.
نویسندگان
چکیده
A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.
منابع مشابه
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 125 42 شماره
صفحات -
تاریخ انتشار 2003