Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents.
نویسندگان
چکیده
The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.
منابع مشابه
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عنوان ژورنال:
- Chemistry
دوره 22 45 شماره
صفحات -
تاریخ انتشار 2016