Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord.

نویسندگان

  • Tong Liu
  • K Christian Donahue
  • Jun Hu
  • Michael P Kurnellas
  • Jennifer E Grant
  • Hong Li
  • Stella Elkabes
چکیده

The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.

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عنوان ژورنال:
  • Journal of proteome research

دوره 6 7  شماره 

صفحات  -

تاریخ انتشار 2007