Probing energy metabolism in the ischemic rat heart with hyperpolarized 13C MRS
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چکیده
Probing energy metabolism in the ischemic rat heart with hyperpolarized 13C MRS Hikari A. I. Yoshihara, Jessica A. M. Bastiaansen, Corinne Berthonneche, Arnaud Comment, and Juerg Schwitter Division of Cardiology, Lausanne University Hospital, Lausanne, Switzerland, Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, Switzerland, Cardiovascular Assessment Facility, Lausanne University Hospital, Switzerland, Division of Cardiology and Cardiac MR Center, Lausanne University Hospital, Switzerland
منابع مشابه
Assessing ischemic myocardial metabolism in vivo with hyperpolarized 13C: relating the metabolic perturbation to the area at risk
Background The high metabolic activity of the heart makes it particularly suited to the use of hyperpolarized (HP) 13C methods to non-invasively detect and characterize metabolic changes that occur during ischemia/reperfusion (I/R). Energy metabolism in ischemic rat hearts has been previously interrogated with HP 13C-labelled pyruvate ex vivo, and its hyperpolarized metabolites have been imaged...
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Hyperpolarized carbon-13 magnetic resonance spectroscopy ((13)C MRS) enables the sensitive and noninvasive assessment of the metabolic changes occurring during myocardial ischemia-reperfusion. Ischemia-reperfusion models using hyperpolarized (13)C MRS are established in heart preparations ex vivo and in large animals in vivo, but an in vivo model in small animals would be advantageous to allow ...
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تاریخ انتشار 2013