Ligand-assisted palladium-catalyzed C–H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines

Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp3)−H Activation

A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C-H activation flow process and illustrates an approach towards first...

Palladium-catalyzed direct C-3 oxidative alkenylation of phosphachromones.

A method for the synthesis of C-3 alkenylated phosphachromones was developed using a direct intermolecular C-3 alkenylation with activated and non-activated alkenes through C-H activation under aerobic conditions.

Enantioselective amine α-functionalization via palladium catalyzed C–H arylation of thioamides

Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered in bioactive compounds and approved therapeutic agents. These N-heterocycles are also incorporated as chiral auxiliaries and ligands in asymmetric synthesis. As such, the development of methods to functionalize the α-methylene C-H bonds of these systems enantioselectively is of great importance, espec...

Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones via carbonylation of γ-C(sp3)–H bonds of aliphatic amine substrates† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data for all new compounds. CCDC 1048649. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00519a

Palladium-catalyzed ortho-C-H alkenylation of 2-benzyl-1,2,3-triazoles.

A mild and efficient method for the direct alkenylation of 2-benzyl-1,2,3-triazoles via Pd-catalyzed C-H bond activation was developed. This protocol was compatible with various substrates and gave the corresponding products in good to excellent yields. Thus, the present study provides a novel and valuable method for the synthesis of 2-benzyl-1,2,3-triazole derivatives.