Anemia of chronic disease in patients with rheumatoid arthritis--use of zinc protoporphyrin (ZPP) levels.
نویسندگان
چکیده
منابع مشابه
Zinc protoporphyrin in anemia of chronic disorders.
Hematofluorometric determination of zinc protoporphyrin (ZPP) is a screening method for the assessment of iron deficiency (ID). Chronic disorders are frequently accompanied by anemias of unclear origin, most probably caused by an impairment of iron metabolism. We investigated the relevance of ZPP for the detection of derangements of iron metabolism in anemias of chronic disorders (ACD). In 19 p...
متن کاملCentral role of zinc protoporphyrin in staging iron deficiency.
In iron deficiency, zinc protoporphyrin (ZPP) is produced instead of heme, and the ZPP concentration in erythrocytes is increased (normal < or = 40 mumol/mol heme). We investigated the relevance of ZPP for staging iron deficiency. ZPP was determined by hematofluorometry in samples from 103 patients. Nineteen patients with iron depletion showed decreased serum ferritin (12.1 +/- 4.4 micrograms/L...
متن کاملThe elevation of blood levels of zinc protoporphyrin in mice following whole body irradiation.
Elevation of zinc protoporphyrin (ZPP) levels in the blood has served as an indicator of lead poisoning and iron deficiency anemia for many years. We have discovered that sublethal doses of whole body irradiation with x-rays also elevates ZPP 2-3-fold over normal levels. The ZPP level does not begin to increase until days 12-14 postirradiation and peaks between days 18 and 20 before returning t...
متن کاملZinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency.
OBJECTIVE Iron deficiency anemia is known to impair cognitive and psychomotor development. The zinc protoporphyrin/heme (ZPP/H) ratio is a simple, accurate, and sensitive laboratory screening test that detects early iron depletion before the onset of anemia. The objective of this work was to evaluate this test in a primary pediatric practice setting. METHODS The iron status of a cohort of 361...
متن کاملZinc protoporphyrin and iron deficiency screening: trends and therapeutic response in an urban pediatric center.
IMPORTANCE Iron deficiency is the most common micronutrient deficiency among children worldwide, with iron-deficiency anemia associated with long-term adverse neurodevelopmental effects. OBJECTIVE To understand the role of zinc protoporphyrin (ZPP) in iron deficiency screening in a low-income pediatric population, as well as to describe the prevalence and trends of abnormal ZPP and the respon...
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عنوان ژورنال:
- The Journal of rheumatology
دوره 34 2 شماره
صفحات -
تاریخ انتشار 2007