Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
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Citation Bonocora, R. P. et al. " A Homing Endonuclease and the 50-nt Ribosomal Bypass Sequence of Phage T4 Constitute a Mobile DNA Cassette. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.
منابع مشابه
Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
BACKGROUND The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address "food-abuse" disorders. We demonstrate a molecular link between impairment of a central kinase (Akt) involved in insulin signaling induced by exposure to a high-fat (HF) diet and dysregulation of higher order circuitry involved i...
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Disrupted neuronal protein kinase B (Akt) signaling has been associated with dopamine (DA)-related neuropsychiatric disorders, including schizophrenia, a devastating mental illness. We hypothesize that proper DA neurotransmission is therefore dependent upon intact neuronal Akt function. Akt is activated by phosphorylation of two key residues: Thr308 and Ser473. Blunted Akt phosphorylation at Se...
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تاریخ انتشار 2011