A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion.
نویسندگان
چکیده
A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.
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عنوان ژورنال:
- Chemical communications
دوره 48 76 شماره
صفحات -
تاریخ انتشار 2012