Kinetic studies on metabolism of lipoprotein lipase.

Since Hahn demonstrated the clearing of alimentary lipemia by the intravenous injection of heparin, many excellent studies have been done on lipoprotein lipase (LPL). In these studies, however, LPL activities were compared in normal and pathological conditions at a certain time after heparin injection. If the level of LPL activity in the circulating blood changes continuously after heparin injection, under the influences of production and inactivation of LPL, it may be much more useful, under certain circumnstances, to measure the rate of change as well as the amount of such activity. One of the authors reported previously (1) the method of estimating the release or production rate and inactivation rate of LPL after heparin injection. This report will present the data on the metabolism of LPL activity in blood after the intravenous injection of heparin in normal subjects and patients with liver diseases, obesity, and coronary sclerosis, and in some animals.