Tetrahydrobiopterin and endothelial nitric oxide synthase activity.
نویسندگان
چکیده
منابع مشابه
EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
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The present study was designed to investigate the interaction between 5-methyltetrahydrofolate and tetrahydrobiopterin in modulating endothelial function. Tetrahydrobiopterin is a critical cofactor for nitric oxide synthase and maintains this enzyme as a nitric oxide- versus superoxide-producing enzyme. The structure of 5-methyltetrahydrofolate is similar to tetrahydrobiopterin and both agents ...
متن کاملTetrahydrobiopterin restores endothelial function in hypercholesterolemia.
In hypercholesterolemia, impaired nitric oxide activity has been associated with increased nitric oxide degradation by oxygen radicals. Deficiency of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase, causes both impaired nitric oxide activity and increased oxygen radical formation. In this study we tested whether tetrahydrobiopterin deficiency contributes to the decreased nit...
متن کاملLong-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
In cultured endothelial cells, the antioxidant, L-ascorbic acid (vitamin C), increases nitric oxide synthase (NOS) enzyme activity via chemical stabilization of tetrahydrobiopterin. Our objective was to determine the effect of vitamin C on NOS function and tetrahydrobiopterin metabolism in vivo. Twenty-six to twenty-eight weeks of diet supplementation with vitamin C (1%/kg chow) significantly i...
متن کاملTargeted increases in endothelial cell superoxide anion production stimulate eNOS-dependent nitric oxide production, not uncoupled eNOS activity.
Every once in a while a paper comes along that makes us question our understanding of cell biology. Current theory holds that oxidative stress increases oxidation of tetrahydrobiopterin (BH4), which in turn uncouples endothelial nitric oxide synthase (eNOS) activity. Numerous publications, using a variety of experimental approaches, provide strong support for the BH4 oxidation hypothesis. Indee...
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عنوان ژورنال:
- Cardiovascular research
دوره 43 2 شماره
صفحات -
تاریخ انتشار 1999