Nts on the Vaccination of Human Beings With

A previous communicat ion (1) outl ined the prophylac t ic effect in M. mulatta <ff formolinac t iva ted suspensions of mumps virus prepared from the infected p a r o t i d gland. I t was shown tha t the inject ion of such mater ia l led, in the ma jo r i t y of animals, to the product ion of specific complement-fixing an t ibody . M o r e o v e r in about 60 per cent of the vaccinated animals evidence of increased resis tance on challenge with act ive mumps virus was obtained. In view of the results in monkeys, similar exper iments were carried out in h u m a n beings employing the complement fixation tes t and the skin test , which have been recent ly described (2--4), as means of selecting individuals p resumpt ive ly susceptible to mumps. The present repor t reviews these invest igat ions.