CLINICAL TRIALS AND OBSERVATIONS Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children’s Oncology Group and SWOG
نویسندگان
چکیده
Phoenix A. Ho,1,2 Kenneth J. Kopecky,3 Todd A. Alonzo,4,5 Robert B. Gerbing,4 Kristen L. Miller,1 Julia Kuhn,1 Rong Zeng,1 Rhonda E. Ries,1 Susana C. Raimondi,6 Betsy A. Hirsch,7 Vivian Oehler,1,8 Craig A. Hurwitz,9 Janet L. Franklin,10,11 Alan S. Gamis,12 Stephen H. Petersdorf,8 Jeanne E. Anderson,13 John E. Godwin,14 Gregory H. Reaman,15 Cheryl L. Willman,16 Irwin D. Bernstein,1,2 Jerald P. Radich,1,8 Frederick R. Appelbaum,1,8 Derek L. Stirewalt,1,8 and Soheil Meshinchi1,2
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children’s Oncology Group
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2Division of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle; 3Children’s Oncology Group, Arcadia, CA; 4Department of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles; 5Division of Medical Oncology, Seattle Cancer Care Alliance/University of...
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1Division of Hematology/Oncology/BMT, BC’s Children’s Hospital, Vancouver, BC, Canada; 2Department of Preventive Medicine, University of Southern California, Los Angeles; 3Children’s Oncology Group, Arcadia, CA; 4Fred Hutchinson Cancer Research Center, Seattle, WA; 5Department of Pathology, Ohio State University, Columbus; 6Division of Pediatric Hematology/Oncology, IWK Health Center, Halifax, ...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children’s Cancer Group (CCG)
1Children’s Oncology Group, Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplantation, BC Children’s Hospital, University of British Columbia, Vancouver, Canada; 2Department of Pediatrics, University of Mississippi Medical Center, Jackson; 3Department of Preventative Medicine, University of Southern California, Los Angeles; 4Children’s Oncology Group Statistics and D...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genomewide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5....
متن کاملCLINICAL TRIALS AND OBSERVATIONS IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
Mutations in the IDH1 gene at position R132 coding for the enzyme cytosolic isocitrate dehydrogenase are known in glioma and have recently been detected also in acute myeloid leukemia (AML). These mutations result in an accumulation of -ketoglutarate to R (2)-2-hydroxyglutarate (2HG). To further clarify the role of this mutation in AML, we have analyzed IDH1R132 in 1414 AML patients. We detecte...
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تاریخ انتشار 2011