Directed self-assembly of lipid nanotubes from inverted hexagonal structures.

نویسندگان

  • Kaori Sugihara
  • Mohamed Chami
  • Imre Derényi
  • János Vörös
  • Tomaso Zambelli
چکیده

Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.

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عنوان ژورنال:
  • ACS nano

دوره 6 8  شماره 

صفحات  -

تاریخ انتشار 2012