Effects of Chlorambucil and Therapeutic Decision in Initial Forms of Chronic Lymphocytic Leukemia (Stage
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چکیده
In 1980, the French Cooperative Group on Chronic Lymphocytic Leukemia started a randomized clinical trial in which 612 good prognosis patients (stage A) received either no treatment (309 patients) or an indefinite course of chlorambucil at the daily dose of 0.1 mg/kg (303 patients). Overall survival appeared to be better in the untreated group (50 deceased patients compared with 62 in the chlorambucil group), but the difference was not significant ( P = .21) even after adjusting for both prognostic and imbalanced factors ( P = .09). The crude 5-year survival rates were 82% in the untreated group and 75% in the chlorambucil group. The action of chlorambucil appeared to be a complex phenomenon associating beneficial effects consisting in slowing down disease progression to stage B or C (P < .OIL and favoring disease remission with harmful
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تاریخ انتشار 2003