Quantitative Determination of drugs & pharnaceuticalsby using iodine as analytical reagent: A spectrophotometric study

Sensitive, accurate and precise methods for the qauantitative determination of Seven drugs viz., Cyclobenzaprine HCl (CYC), Cyproheptadine HCl (CYP), Dobutamine HCl (DOB), Moxifloxacin HCl (MOX), Pamiprioxole HCl (PAM), Sumatriptan succinate (SUM) and Trimetazadine 2HCl(TRI) haave been developed . The methods are based on the charge transfer interqction of iodine with drugs which resulted in the formation of I3 ion with absorbtion maximum at 366nm. The absorbance of the band increased with increasing concentration of the drug and formed basis for the quantitative determination of the drugs. The methods have been validated in terms of ICH guidelines and parameters affecting the absorbance are optimised.The stoichiometry of each of the CT complex is found to be 1:1 by Job’s continuous varuiation methodts and the formation constants are determined by drawing tangents to the Job’s plots