Unraveling the intricacies of mammalian fertilization

More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding

P-91: The Effects of Mesenchymal StemCell- Conditioned Medium on The Fertilization Rate and Embryo Development inNMRI Mice

Background: Normal growth of oocytes, embryos and also successful implantation depend on environmental factors such as the secretion of cumulus cells and composition of follicular and tubular fluids. Therefore, addition of serum, conditioned medium (CM) to the culture medium and also co-culture with somatic cells improve mammalian embryo development. So, in the respect to the secretion of diffe...

P-65: Maternal Effect Genes in Mammalian Reproduction

Background: Regulation of gene expression in mammalian embryos is not completely known. Pre-implantation embryos need maternal RNA and proteins synthesized during oogenesis, to regulate development before mater-embryo transition, as the grown oocyte and the 1-cell zygote are transcriptionally silent. There are some oocyte-specific genes called maternal effect genes which may account for this ea...

Ion channels, phosphorylation and mammalian sperm capacitation.

Sexually reproducing animals require an orchestrated communication between spermatozoa and the egg to generate a new individual. Capacitation, a maturational complex phenomenon that occurs in the female reproductive tract, renders spermatozoa capable of binding and fusing with the oocyte, and it is a requirement for mammalian fertilization. Capacitation encompasses plasma membrane reorganizatio...

Sugar‐coated sperm: Unraveling the functions of the mammalian sperm glycocalyx

Mammalian spermatozoa are coated with a thick glycocalyx that is assembled during sperm development, maturation, and upon contact with seminal fluid. The sperm glycocalyx is critical for sperm survival in the female reproductive tract and is modified during capacitation. The complex interplay among the various glycoconjugates generates numerous signaling motifs that may regulate sperm function ...