Management of head injuries.

This book contains the Bertha Memorial Lecture and fifty-three papers selected for presentation at the 11th World Federation of Neurology Meeting held in Salzburg in September 1982. The papers are divided into five sections covering Regulation of Cerebral Blood Flow and Risk Factors, Neuroimaging Techniques, Critical Evaluation of Therapeutic Approaches, Cerebral Perfusion and Metabolism in Relation to Function, and Migraine. In the Bertha Memorial Lecture Sokoloff outlines the principles behind the 2-deoxy-D-glucose method of studying glucose metabolism and illustrates the impressive results obtained by autoradiography in studying the close coupling between local functional activity and local glucose metabolism. For example, in the rat, the rates of glucose utilisation in the primary projection areas of the retina are directly proportional to the logarithm of the intensity of retinal illumination. The deoxy-glucose method can now be applied to man using positron emission tomography (PET) though the resolution is lower than that obtained by autoradiography. Using this method WD Heiss et al have shown reduced cerebral metabolism distant to the site of infarction and suggest that in part this is due to deafferentation. Other