Automated Targeted Screening of Leachables in Pharmaceutical QC Labs Using the Agilent LC/MSD XT and Agilent OpenLAB CDS
ثبت نشده
چکیده
This Application Note describes a routine analysis workflow for pharmaceutical QA/QC labs. Organic nonvolatile leachables from ophthalmic drug products were identified and quantified using an Agilent Liquid Chromatograph/Mass Selective Detector XT (LC/MSD XT), based on single quadrupole technology, with the Agilent 1260 Infinity II LC system and Agilent OpenLAB CDS Software. The newly designed OpenLAB CDS has several advantages for targeted screening, such as reference spectral matching, quantification with quantifier and qualifier ions, and suspect identification using library searches. The software enables a complete 21 CFR Part 11 compliance solution that includes data security, integrity, and
منابع مشابه
Automated Purification Software for Agilent OpenLAB CDS
Agilent 1260 Infinity LC and LC/MS purification systems offer flexible and easy‐to‐use solutions for purification of microgram to gram quantities of samples, with maximum levels of recovery and purity. Using combined or dedicated analytical and preparative‐scale systems configured to meet the throughput demands of your laboratory, the Agilent Automated Purification Software automates the transf...
متن کاملLC/Q-TOF Workflows for Comprehensive Micropollutant Analysis Targeted Quantification, Suspect Screening, and Unknown Compound Identification
This application note presents three complementary LC/Q-TOF workflows designed to provide comprehensive analysis of micropollutants in surface waters: • Targeted quantification • Suspect screening with and without MS/MS spectra • Unknown compound identification The first two workflows rely on the Agilent All Ions MS/MS accurate mass capabilities of the Agilent LC/Q-TOF system, Agilent MassHunte...
متن کاملFast screening of mobile and stationary phases with the Agilent 1290 Infinity LC and seamless method transfer to an Agilent 1200 Series LC using ISET
This Application Note describes how the Agilent 1290 Infinity LC System Method Development Solution was used to find optimum separation conditions for degradation products of a pharmaceutical preparation. Having evaluated the optimum combination, a transfer to conventional conditions was performed. Finally, the Agilent Intelligent System Emulation Technology (ISET) of the 1290 Infinity LC was u...
متن کاملIntegration of Agilent UV-Visible ChemStation with OpenLAB ECM
The intent of these guidelines is to ensure that applicable electronic records are reliable, authentic and maintained with high integrity. This technical note describes features and functionality of Agilent UV-Visible ChemStation (revision B.05.XX) in combination with Agilent OpenLAB Enterprise Content Manager (ECM) for data management, which enable customers to implement the guidelines of 21 C...
متن کاملSoftware assisted identification of metabo- lites from pharmaceutical drugs using the Agilent 1290 Infinity LC System with an Agilent 6530 Q-TOF MS System and the expert prediction system Meteor
This Application Note describes: • The separation of metabolites from a pharmaceutical drug on an Agilent 1290 Infinity LC System • The generation of mass spectral data on an Agilent 6530 Accurate-Mass Q-TOF liquid chromatograph/mass spectrometer (LC/MS) • The introduction of results from the expert metabolism prediction software Meteor (Lhasa Limited, Leeds, UK) into the Agilent MassHunter Met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017