Conformational Ensembles in GPCR Activation
نویسندگان
چکیده
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
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عنوان ژورنال:
- Cell
دوره 152 شماره
صفحات -
تاریخ انتشار 2013