Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture

Neural Cell Adhesion Between Spinal Cord Molecule Mediates Initial Interactions Neurons and Muscle Cells in Culture

Previous studies in this laboratory have described a cell surface glycoprotein, called neural cell adhesion molecule or N-CAM, that appears to be a ligand in the adhesion between neural membranes. N-CAM antigenic determinants were also shown to be present on embryonic muscle and an N-CAM-dependent adhesion was demonstrated between retinal cell membranes and muscle cells in short-term assays. Th...

Functional effects of transplanted embryonic stem cell-derived neural aggregates overexpressing the neural cell adhesion molecule L1 in the MPTP model of Parkinson's disease and in a spinal cord injury model in Mus musculus (Linnaeus, 1758)

Neuritic deposition of agrin on culture substrate: implications for nerve-muscle synaptogenesis.

Recent experiments have indicated that neural agrin is deposited at newly forming nerve-muscle synapses and has a primary synaptogenic role there. As a step toward assessing how the spatial arrangement of new synaptic sites is regulated, we compared the pattern of agrin deposition by Xenopus neurites on culture substrate and on muscle cells. The neurons were grown on a substrate that bound thei...

The Proliferation Study of hiPS Cell-Derived Neuronal Progenitors on Poly-Caprolactone Scaffold

Introduction: The native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. Considering the suitable characteristics of induced pluripotent stem cells (iPSCs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...

The effect of Fibroblast Growth Factor-2(FGF-2) and retinoic acid on differentiation of mouse embryonic stem cells into neural cells

Introduction: Embryonic Stem (ES) cells as pluripotent cells derived from the inner cell mass of blastula can differentiate to neural cells in vitro and this property is valuable in studies of neurogenesis and in the generation of donor cells for transplantation. In this regard, the propose of this research, was the study of the role of two important factors in the development of neural syst...