03-P026 Retinoic acid – planar cell polarity crosstalk during neural tube closure

at the middle stage of regeneration. When we observed the expression of tail marker genes such as DjAbd-Ba, their expression could be detected at the early stage of regeneration, but was not increased after the middle stage of regeneration in DjlimA(RNAi). Based on these findings combined with histological observations, we concluded that DjlimA may be required for maintaining the proper morphological events during the middle stage of regeneration in planarians, but not at the early stage. This is the first report suggesting that initiation and maintenance events during regeneration could be separated by differential activity of transcription factor(s).