Failure to demonstrate specific antibody in transmissible mink encephalopathy.
نویسندگان
چکیده
Attempts to demonstrate specific serum antibody or immune complexes in the brains of mink affected with transmissible mink encephalopathy were unsuccessful with serum neutralization and immunofluorescent procedures. These data may be significant, considering the unusual nature of the disease and the biochemical properties of the etiological agent.
منابع مشابه
Transmissible mink encephalopathy - review of the etiology of a rare prion disease.
We review here the history, neuropathology, clinical picture and molecular data on transmissible mink encephalopathy (TME). This obscure disease is of utmost importance as it is plausible that it represents a transmission of hidden bovine spongiform encephalopathy (BSE) to mink in the USA. Of special interest is the similarity of L-type of BSE and TME. Furthermore, experimental molecular studie...
متن کاملTransmissible Mink Encephalopathy
Transmissible mink encephalopathy (TME) is a progressive and fatal neurodegenerative disease that affects ranched mink (Neovison (Mustela) vison). Most or all of the adult animals on a ranch may be affected, and once an animal becomes symptomatic, death is inevitable. This disease is still poorly understood. It is very rare, with only a few outbreaks reported in the U.S. and other countries. Ou...
متن کاملUse of bovine recombinant prion protein and real-time quaking-induced conversion to detect cattle transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-Type bovine spongiform encephalopathy
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for in vitro assays including serial protein misfolding amplification and real-time quaking induced conversion (RT-QuIC). RT-QuIC can be used for the ...
متن کاملFirst and second cattle passage of transmissible mink encephalopathy by intracerebral inoculation.
To compare clinicopathologic findings of transmissible mink encephalopathy (TME) with other transmissible spongiform encephalopathies (TSE, prion diseases) that have been shown to be experimentally transmissible to cattle (sheep scrapie and chronic wasting disease [CWD]), two groups of calves (n = 4 each) were intracerebrally inoculated with TME agents from two different sources (mink with TME ...
متن کاملTransmissible mink encephalopathy.
Transmissible mink encephalopathy (TME) is a rare disease of ranch-raised mink caused by exposure to an as yet unidentified contaminated food ingredient in the ration. The clinical and pathological similarities between TME and scrapie, together with the indistinguishable physicochemical characteristics of their transmissible agents, suggest that sheep may be the source of infection. However, ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Infection and immunity
دوره 2 6 شماره
صفحات -
تاریخ انتشار 1970