ENPP 2 ( ectonucleotide pyrophosphatase / phosphodiesterase 2 )

نویسندگان

  • Mary L Stracke
  • Timothy Clair
چکیده

The mRNA for ENPP2 is 3276 bp with exon 12 and 3120 bp without it. The ENPP2 promoter is reported to have four SP1 sites as well as binding sites for NFAT and NF-kappaB but no TATA or CAAT boxes. The only transcription factor that has been proven to increase ENPP2 protein expression is NFATC2/NFAT1, after release of alpha6beta4 from hemidesmosomes in a breast cancer cell line. A number of growth factors have been found to stimulate ENPP2 protein expression, while several inflammatory cytokines have been reported to inhibit expression.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chemical Evolution of Autotaxin Inhibitors

(ATX or ENPP2) was isolated as an autocrine motility factor from melanoma cells. 1 The ∼120 kDa glycoprotein ATX belongs to a small family named ectonucleotide pyrophosphatase and phosphodiesterase (ENPP), which consists of seven family members. 2 ATX is the only ENPP family member with lysophospholipase D (lysoPLD) activity and is responsible for the hydrolysis of lysophosphatidylcholine (LPC)...

متن کامل

Are Basophils and T helper 2 Cells Implicated in Mastocytosis?

Abbreviations: BAT: Basophil Activation Test; CRTH2: G proteincoupled Receptor-44 or Chemoattractant Receptor Expressed on Th2 cells; EDTA-K3: Ethylene-Diamine-Tetracetic Acid; ENPP-3: Ectoenzyme ectonucleotide Pyrophosphatase/Phosphodiesterases 3; IL: Interleukin; ISM: Indolent Systemic Mastocytosis; LAMP: Lysosomal Membrane Proteins; MFI: Median Fluorescence Intensity; PGD2: Prostaglandin D2;...

متن کامل

Transendothelial Migration of Naive T Cells Stimulates Polarization, Motility, and Autotaxin through Lysophosphatidic Acid

متن کامل

Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish

Lysophosphatidic acid (LPA) is a unique bioactive lysophospholipid that induces pleiotropic effects in various cell types and organisms by acting on its specific receptors. LPA is mainly synthetised extracellularly by the ectonucleotide pyrophosphatase/phosphodiesterase 2/autotaxin (enpp2). Altered LPA signalling is associated with embryonic abnormalities, suggesting critical roles for LPA duri...

متن کامل

Autotaxin/Lysophosphatidic Acid Axis Venules Is Regulated by the across the Basal Lamina of High Endothelial Constitutive Lymphocyte Transmigration

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011