[No more excuses… this vaccine, yes!].
نویسنده
چکیده
Streptococcus pneumoniae (S. pneumoniae) is one of the leading pathogens that cause community-acquired infections. It has accumulated genetic mutations throughout its evolution, and at present more than 90 different serotypes of S. pneumoniae are known. Serotypes are identified based on the polysaccharide capsule that surrounds the cell wall. Despite the high number of serotypes, most cases of pneumococcal disease are caused by just a few of them. Serotype prevalence changes depending on time and age, and there is also geographic variation.1 In our setting, S. pneumoniae is the most prevalent causative agent of simple and complicated pneumonia, meningitis, occult bacteraemia, otitis, and acute sinusitis.2 It is estimated that this pathogen causes 14.5 million cases a year of severe invasive pneumococcal disease (IPD) in children younger than 5 years, and is responsible for over half a million deaths that occur mostly in least developed and developing countries.3 Vaccines are one of our main means to fight S. pneumoniae. Unfortunately, the traditional polysaccharide vaccine
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عنوان ژورنال:
- Anales de pediatria
دوره 81 3 شماره
صفحات -
تاریخ انتشار 2014