Continuous quantitative mapping of multi-organ T1 relaxation times with ShMOLLI to assess dose response in respiratory challenges at 3T

Background The performance of T1 mapping as a stable biomarker depends on its sensitivity to pathological changes and relative insensitivity to normal physiological variations or common clinical interventions, such as oxygen administration. We address the impact of breathing air supplemented with oxygen (O2) and/or carbon dioxide (CO2) on T1 values in healthy myocardium and selected extra-cardiac tissues.