The Integrated Web Portal for Escalation with Overdose Control (EWOC)

نویسندگان

  • Haibin Wang
  • Mourad Tighiouart
  • Shao-Chi Huang
  • Dror Berel
  • Galen Cook-Wiens
  • Catherine Bresee
  • Quanlin Li
  • André Rogatko
چکیده

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2013