EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

David Guiliano, Izabela Lenart, Edward Tsao, Nasim Yousaf, Paul Kellam, Greg Towers and Antony N. Antoniou, Division of Infection and Immunity/Centre of Rheumatology, Rayne Building, 5 University Street, University College London, London, WC1E 6JF School of Health, Sport and Bioscience, University of East London, London, E15 4LZ Helen Fussell, Histocompatibility and Immunogenetics Department, NHS Blood and Transplant, Colindale Blood Centre, Colindale Avenue, London, NW9 5BG Darren Nesbeth, The Advanced Centre for Biochemical Engineering, University College London, Gower Street, London, WC1E 7JE Simon J. Powis, Elaine C. Campbell, Sarah Williams, Amy Cameron, School of Medicine,University of St. Andrews, Fife, Scotland, KY16 9TF Susana Santos, INEBInstituto de Engenharia Biomedica, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal Daniel N. Hebert, Biochemistry and Molecular Biology, 701 N. Pleasant St. LGRT 1228, University of Massachusetts, Amherst, MA 01003Keith Gould, WrightFleming Institute, Imperial College London, London, England, W2 1PG *These authors contributed equally to the work. Corresponding author: Antony N. Antoniou Division of Infection and Immunity/Centre of Rheumatology, Rayne Building, 5 University Street, University College London, London, WC1E 6JF Tel:+44-2031082177 Fax:+44-2031082152 Email: [email protected]