Immunological changes after one year of specific immunotherapy with Pru p 3
نویسندگان
چکیده
Rationale In Southern Europe Pru p3 is the primary sensitizer of plants fruit and responsible for severe reactions. Specific immunotherapy (SIT) brings a new perspective to treat anaphylactic patients. There is a lack of knowledge regarding immunological response that includes changes in the basophil activation and antibody production during IT. We aimed to analyse early changes in the basophil response to Pru p 3 and another related allergen (Ara h 9) during the first year of sublingual immunotherapy (SLIT).
منابع مشابه
Are basophil activation and sulphidoleukotriene determination useful tests for monitoring patients with peach allergy receiving sublingual immunotherapy with a Pru p 3-enriched peach extract?
INTRODUCTION Treatment of food allergy essentially consists of food avoidance, but immunotherapy with food is emerging as a new therapeutic option. OBJECTIVE To evaluate clinical improvement and immunological changes in patients with peach allergy following sublingual immunotherapy (SLIT) with a Prup3 quantified peach extract. METHODS A randomized, double-blind, placebo-controlled clinical ...
متن کاملSpecific sublingual immunotherapy with peach LTP (Pru p 3). One year treatment: a case report
INTRODUCTION Food allergy is an increasing problem with limited therapeutic approaches apart from to the eviction diet. CASE PRESENTATION A 40-year-old female patient with food allergy symptoms was polysensitized to almost all vegetable food since the age of 36; the onset of symptoms was during pregnancy. The allergological study demonstrated positive skin prick tests (SPT) to nuts, legumes, ...
متن کاملLPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model
Pru p 3 is the major peach allergen in the Mediterranean area. It frequently elicits severe reactions, limiting its study in humans, raising the need for animal models to investigate the immunological mechanisms involved. However, no anaphylaxis model exists for Pru p 3. We aimed to develop a model of peach anaphylaxis by sensitising mice with Pru p 3 in combination with lipopolysaccharide (LPS...
متن کاملBasophils response to Pru p 3 and Ara h 9 in patients sensitised to peach under specific immunotherapy
Rationale In Southern Europe Pru p3 is the primary sensitizer of plants fruit and it is responsible of severe reactions. Specific immunotherapy (SIT) brings a new perspective to treat those patients. There is a lack of knowledge regarding cellular responses that include changes in the basophil activation during the IT. We aim to analyse early changes in the basophil response to Pru p 3 and othe...
متن کاملPoster 1020: Efficacy and safety of sublingual specific immunotherapy with Pru p 3 in a portuguese population - clinical and immunological evaluation during 12 months
Background Peach allergy is prevalent, persistent and potentially severe. LTPs (Pru p 3) and profilins (Pru p 4) are the main allergens involved in this kind of allergy in patients(pts) of Mediterranean area. The hidden presence of LTPs in foodstuffs and in other food involved in LTP syndrome can trigger severe reactions, including anaphylaxis. Thus, this type of allergy can be considered an im...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2015