Cytosolic Group IVA and Calcium-independent Group VIA Phospholipases A2 Act on Distinct Phospholipid Pools in Zymosan- Stimulated Mouse Peritoneal Macrophages
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Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages.
Phospholipase A2s generate lipid mediators that constitute an important component of the integrated response of macrophages to stimuli of the innate immune response. Because these cells contain multiple phospholipase A2 forms, the challenge is to elucidate the roles that each of these forms plays in regulating normal cellular processes and in disease pathogenesis. A major issue is to precisely ...
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تاریخ انتشار 2015