valuation of diphenyl dimethyl bicarboxylate (DDB) as a probable epato- protector in rats against whole body gamma irradiation

any antioxidants have been studied as hepatoprotectors against ionizing radiation injury ince they reduce the oxidative effect of the reactive oxygen species to normal cells. Diphenyl imethyl bicarboxylate (DDB) has been clinically used against chemically damaged liver since has an antioxidant action for scavenging free radicals and inhibiting lipid peroxidation eactions. Ionizing radiation is known to induce disturbances in serum liver aspartate minotransferase and alanine aminotransferase (AST and ALT), alkaline phosphatase (ALP) ctivities and proteins (total protein, albumin and globulin) levels. The aim of the present work as to evaluate if DDB preor/and posttreatments have a hepatoprotector effect against amma (γ) irradiation damaged liver. DDB was administered daily with a dose of 50 mg/Kg ody weight to whole body irradiated rats with 4.5 Grey (Gy). A follow up period of five weeks ost-irradiation showed an improvement in the disturbed different parameters in the irradiated roup. The pre-treated, post-treated and preand post-treated animals with DDB against radiation showed earlier and potent improvement, since it increased total protein and lbumin levels to near that of the control. On the other hand, DDB reduced the altered activity f AST, ALT and ALP earlier than the irradiated group. It was concluded that all the eatments with DDB have a hepato-radioprotective effect and the preand posttreatment as the most potent effect against the alterations induced by irradiation.