C3sc22205e 2319..2333
نویسندگان
چکیده
Cancers of diverse origins exhibit marked glucose avidity and high rates of aerobic glycolysis. Increased understanding of this dysfunctional metabolism known as the Warburg effect has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting is glycoconjugation, the linking of a drug to glucose or another sugar. This review summarizes the most salient examples of glycoconjugates, in which known cytotoxins or anticancer therapeutics have been linked to glucose (or another glucose transporter substrate sugar) for improved cancer targeting and selectivity. Building on these examples, this review also provides a series of guidelines for the design and mechanistic evaluation of future glycoconjugates.
منابع مشابه
New Insights into the Anthracnose Resistance of Common Bean Landrace
The common bean landrace G 2333 carries a three gene pyramid for anthracnose resistance: Co-4 2 , Co-5 and Co-7. The Co-4 2 gene is well characterized but less information is available on Co-5 and Co-7. The objectives of this study were to determine if a new allele of Co-5 is present in G 2333; to characterize the spectrum of resistance conditioned by the Co-7 gene by deriving lines which only ...
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تاریخ انتشار 2013