Intrinsic Neurophysiological Properties of Hilar Ectopic and 1 Normotopic Dentate Granule Cells in Human Temporal Lobe
نویسندگان
چکیده
1 NORMOTOPIC DENTATE GRANULE CELLS IN HUMAN TEMPORAL LOBE 2 EPILEPSY AND A RAT MODEL. 3 4 Authors 5 Althaus AL 1,3 – Collected and analyzed data, wrote manuscript 6 Sagher O 2 – Obtained IRB approval, consented patients, resected human hippocampal 7 tissue, contributed to manuscript writing 8 Parent JM 1,3 – Developed experimental design, contributed to manuscript writing 9 Murphy GG 1,4,5 – Collected data, developed experimental design, wrote manuscript 10 11 Affiliations 12 1. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 13 2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI 14 3. Department of Neurology, University of Michigan, Ann Arbor, MI 15 4. Department of Molecular and Integrative Physiology, University of Michigan, Ann 16 Arbor, MI 17 5. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann 18 Arbor, MI 19 20 Running Head 21 DGC Neurophysiology in Human & Rat TLE 22 23 Corresponding Author: 24 Geoffrey G Murphy, Ph.D. 25 University of Michigan 26 5037 BSRB 27 109 Zina Pitcher Place 28 Ann Arbor, MI 48109 29 Phone: (734) 936-8926 30 Email: [email protected] 31 32
منابع مشابه
Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability within the epileptic hippocampal network. Here we investigate the intrinsic excitability of DGCs from humans with TLE and the ra...
متن کاملEnhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.
In temporal lobe epilepsy, loss of inhibitory neurons and circuit changes in the dentate gyrus promote hyperexcitability. This hyperexcitability is compensated to the point that dentate granule cells exhibit normal or even subnormal excitability under some conditions. This study explored the possibility that compensation involves enhanced tonic GABA inhibition. Whole cell patch-clamp recordings...
متن کاملThe Effect of Paxilline on Early Alterations of Electrophysiological Properties of Dentate Gyrus Granule Cells in Pilocarpine-Treated Rats
The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...
متن کاملThe Effect of Paxilline on Early Alterations of Electrophysiological Properties of Dentate Gyrus Granule Cells in Pilocarpine-Treated Rats
The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...
متن کاملHigh ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.
After experimental status epilepticus, many dentate granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar ectopic granule cells (HEGCs) have also been found in persons with epilepsy. These cells exhibit a high rate of spontaneous activity, which may enhance seizure propagation. Electron microscopic studies indicated that HEGCs receive more recurren...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014