Complement-dependent anaphylactic reactions.
نویسندگان
چکیده
The concept of elicitation of reactions of anaphylactic type by non-tissue-fixing antibody, through activation of complement and release of anaphylatoxins by antigen-antibody complexes in vivo, is not clearly defined by published evidence. Experimental data are presented to demonstrate that guinea pig immunoglobulin G2 (noncytotropic) complexed with antigen in vitro elicits dermal reactions in guinea pigs, and that pretreatment of animals with complement-inactivating cobra venom factor diminishes such reactions. The various pathways through which immediate hypersensitive reactions may occur are discussed.
منابع مشابه
Sialic acid residues are essential for the anaphylactic activity of murine IgG1 antibodies.
Glycosylation of the Ab molecule is essential for maintaining the functional structure of Fc region and consequently for Ab-mediated effector functions, such as binding to cells or complement system activation. Alterations in the composition of the sugar moiety can dramatically influence Ab activity; however, it is not completely clear how differences in the N-linked oligosaccharide structure i...
متن کاملMechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and implicate a diversity of pathways. Some of these mechanisms may be key to the development of the anaphylactic reaction, while others may only ...
متن کاملShort-term anaphylactic IgG antibodies in human sera.
Apparently pure IgG fractions of some human sera contain antibodies conferring passive cutaneous anaphylactic sensitivity on monkey skin for 1 to 4 hours. This property is heatstable at 56°C for 2 hours and is complement-dependent; it is not neutrophil-dependent; and the antibody does not confer anaphylactic sensitivity on guineapig skin. These short-term passive sensitising antibodies probably...
متن کاملThe Immunological Behaviour of the Second Protein (livetin) of Hen's Egg Yolk
A comparison of the livetin of egg yolk and serum globulin of the common fowl using (a) anaphylactic and (b) precipitin reactions, indicates that the two proteins are very closely related, if not identical. The complement fixation test does not give the same result but indicates a difference between the two proteins. The complement fixation test also shows differences between serum euglobulin a...
متن کاملIgA-induced anaphylactic transfusion reactions: a report of four cases.
Anaphylactic reactions after transfusion of a small amount of red cell compatible blood is described. Typical manifestations were substernal pain, dyspnea, and severe normovolemic shock. All the four patients lacked IgA and were found to have antibodies to IgA with titers from 500 to 16,000, as determined by a passive hemagglutination assay. In immunodiffusion against IgA, a single precipitatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Infection and immunity
دوره 11 6 شماره
صفحات -
تاریخ انتشار 1975