2-Fluoro-l-histidine
نویسندگان
چکیده
The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C atom, indicating an increase in π-bond character due to an inductive effect of fluorine.
منابع مشابه
Synthesis of 2’-Deoxy-2’-fluoro-L-arabinofuranosyl Imidazole Derivatives
The last few years have witnessed a revival of interest in analogues of nucleosides following the discoveries that several of such compounds exhibit powerful antiviral effects. Structural modifications of naturally occurring nucleosides often lead to the discovery of new agents displaying biological and chemotherapeutic activity. A greal deal of effort has been directed towards the modification...
متن کاملThermodynamics for complex of L-histidine with molybdenum (VI) Model Anticancer Drugs
Organometallic complexes offer potential for design as anticancer drugs. A quantitativemodel that discriminates anticancer compounds from the inactive ones in a training series wasEquilibrium of the reaction of molybdenum (VI) with l-histidine have been studiedin aqueous solutions at pH range of 4-8, using spectrophotometry and optical rotationmethods at constant ionic strength of 0.15 mol.lit-...
متن کاملThe chemistry and identification of im-dinitrophenyl histidine.
im-Dinitrophenyl histidine does not decompose under the standard conditions of protein hydrolysis, and it emerges between phenylalanine and lysine on the short column of the amino acid analyzer. Its ninhydrin color constant was found to be 76% of that for histidine. A method for analysis of im-dinitrophenyl histidine in a reacted protein is described. I-Fluoro-2,4-dinitrobenzene reacts preferen...
متن کاملCalixarene Drug deleivery invistegation of Calixarene compounds with conection by histidine L and D stereochemistry
In this research, Quantum-mechanical calculations were performed at the HF method with the 6-31+G*basis set and at the B3LYP method with the 6-31+G* basis set in the gas phase and five solvents such as water, DMSO, methanol, ethanol and dichloromethane at six temperatures. According to these theoretical results of IR, we extracted thermo chemical parameters such as enthalpy (∆H Kcal/mol), Gibbs...
متن کاملMicrowave-assisted Solid-phase(SPPS) and Solution-phase (SPS) Synthesis of Biological Dipeptide ((β-alanine-L histidine)
Peptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexamined...
متن کامل