Semisynthetic modification of antibiotic lincomycin.

as celesticetin2) (2) have been prepared3) by synthetic anc microbiological transformation, involving modificatior of the parent antibiotics both at the sugar moiety anc the amino acid side-chain (Fig. 1). Of these new derivatives 7(S)-chloro-7-deoxylincomycin4) (3, cleocin, clindamycin) is one of the most important, possessing mon pronounced and wider spectrum of antibiotic activity, a* well as enhanced absorption capability than lincomycir (1).