Author's response to reviews Title: Gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze exerts cytotoxic activity and increases sensitivity to doxorubicin treatment in a leukemia
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A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line
BACKGROUND Enhancement of tumor cell sensitivity may help facilitate a reduction in drug dosage using conventional chemotherapies. Consequently, it is worthwhile to search for adjuvants with the potential of increasing chemotherapeutic drug effectiveness and improving patient quality of life. Natural products are a very good source of such adjuvants. METHODS The biological activity of a fract...
متن کاملGallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model
BACKGROUND Several treatment alternatives are available for primary breast cancer, although those for metastatic disease or inflammation associated with tumor progression are ineffective. Therefore, there is a great need for new therapeutic alternatives capable of generating an immune response against residual tumor cells, thus contributing to eradication of micrometastases and cancer stem cell...
متن کاملAntimicrobial, Antioxidant and Cytotoxic Potential of Caesalpinia pulcherrima Flower
Most of the world’s populations residing in developing countries depend on alternative medicine and use of plant ingredients. Caesalpinia pulcherrima (Fabaceae) is used in folk medicine for the treatment of various diseases including asthma, bronchitis, cholera, diarrhea, dysentery and malarial infection. The present study was undertaken to determine antimicrobial, antioxidant and cytotoxic act...
متن کاملEvaluation of the cytotoxic effect of the Brittle Star (Ophiocomaerinaceus) dichloromethane extract and doxorubicin on EL4 cell line
Leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. Nature has been known as a rich source of medically useful substances. High diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. The study has been done to investigate cytotoxic effects of dichloromethane brittl...
متن کاملEvaluation of the cytotoxic effect of the Brittle Star (Ophiocomaerinaceus) dichloromethane extract and doxorubicin on EL4 cell line
Leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. Nature has been known as a rich source of medically useful substances. High diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. The study has been done to investigate cytotoxic effects of dichloromethane brittl...
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تاریخ انتشار 2011