Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00472a Click here for additional data file.

Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers.

The development of novel therapeutic strategies allowing the destruction of tumour cells while sparing healthy tissues is one of the main challenges of cancer chemotherapy. Here, we report on the design and antitumour activity of a low-molecular-weight drug delivery system programmed for the selective release of the potent monomethylauristatin E in the tumour microenvironment of solid tumours. ...

Transformable H-bonds and conformation in compressed glucose† †Electronic supplementary information (ESI) available: Detailed experimental data; detailed structural data. CCDC 1033994–1034008. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03588g Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging† †Electronic supplementary information (ESI) available: Synthetic procedures and experimental details. See DOI: 10.1039/c6sc05251g Click here for additional data file.

Division of Chemistry and Biological Chem Sciences, Nanyang Technological Universit Singapore. E-mail: [email protected] Division of Structural Biology & Biochemist Technological University, Singapore 639798 School of Chemical & Biomedical Enginee Singapore 637459, Singapore Lee Kong Chian School of Medicine, Nany 308232, Singapore Department of Genetic Engineering, Colleg Yongin-si, Gyeonggi-d...

Systematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins† †Electronic supplementary information (ESI) available: Alternative evaluation of the HEDS assay with ScGrx7 (Fig. S1), HEDS and GSSEtOH assay with PfGrx (Fig. S2), enzyme parameters for the GSSEtOH assay with ScGrx7 (Table S1) and calculations of estimated reaction velocities and substrate concentrations (Tables S2–4). See DOI: 10.1039/c5sc01051a Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Analysis of enzyme-responsive peptide surfaces by Raman spectroscopy† †Electronic supplementary information (ESI) available: Detail information about materials and instrumentation, sample preparation, synthesis details and characterisation. See DOI: 10.1039/c5cc09189f Click here for additional data file.