Interplay between DNA supercoiling and transcription elongation.
نویسندگان
چکیده
Transcription-coupled DNA supercoiling has been shown to be an important regulator of transcription that is broadly present in the cell. Here we review experimental work which shows that RNA polymerase is a powerful torsional motor that can alter DNA topology and structure, and DNA supercoiling in turn directly affects transcription elongation.
منابع مشابه
Relaxation of transcription-induced negative supercoiling is an essential function of Escherichia coli DNA topoisomerase I.
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عنوان ژورنال:
- Transcription
دوره 5 شماره
صفحات -
تاریخ انتشار 2014