SHORT COMMUNICATION Chameleon sequences in the PDB

نویسنده

  • Mihaly Mezei
چکیده

There has been recent interest in exploring the possibilities of a given amino acid sequence assuming different secondary structures in different contexts. An 11-residue segment of a synthetic protein was successfully designed that formed an α helix in one context and a β sheet in another, prompting the authors to dub it a ‘chameleon’ sequence (Minor and Kim, 1996). On a larger scale, a 56-residue protein domain was successfully converted to a different fold by changing no more than half of the residues (Dalal et al., 1997). The fact that this achievement was prompted by a challenge supplemented by a monetary prize by some of the leaders in the protein folding field (Rose and Creamer, 1994) indicates the strength of the belief that the secondary structure of a protein is essentially determined locally by the primary structure.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

NetCSSP: web application for predicting chameleon sequences and amyloid fibril formation

The calculation of contact-dependent secondary structure propensity (CSSP) is a unique and sensitive method that detects non-native secondary structure propensities in protein sequences. This method has applications in predicting local conformational change, which typically is observed in core sequences of protein aggregation and amyloid fibril formation. NetCSSP implements the latest version o...

متن کامل

Short communication Chameleons and vineyards in the Western Cape of South Africa: Is automated grape harvesting a threat to the Cape Dwarf Chameleon (Bradypodion pumilum)?

—The use of automated grape harvesters in the Cape Wine Growing region has resulted in controversy regarding their effect on the chameleon Bradypodion pumilum. We investigated densities of B. pumilum during harvesting at a vineyard near Stellenbosch, South Africa. During dedicated surveys, no chameleons were found in vines, while vegetation surrounding the vines contained densities as high as 1...

متن کامل

REES SHORT EXACT SEQUENCES OF S-POSETS

In this paper the notion of Rees short exact sequence for S-posets is introduced, and we investigate the conditions for which these sequences are left or right split. Unlike the case for S-acts, being right split does not imply left split. Furthermore, we present equivalent conditions of a right S-poset P for the functor Hom(P;-) to be exact.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1998