Potassium currents dynamically set the 4 recruitment and firing properties of F - type 5 motoneurons in neonatal mice

نویسنده

  • Felix Leroy
چکیده

Address for Correspondence: Felix Leroy 27 Centre de Neurophysique, Physiologie et Pathologie, UMR 8119 28 Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France 29 *present address: Dr Steve Siegelbaum lab,Columbia University Medical Center, 30 New York State Psychiatric Institute,1051 Riverside Drive New York, NY 10032 31 e-mail: [email protected] 32 33 34 35 Articles in PresS. J Neurophysiol (August 12, 2015). doi:10.1152/jn.00193.2015

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice.

In neonatal mice, fast- and slow-type motoneurons display different patterns of discharge. In response to a long liminal current pulse, the discharge is delayed up to several seconds in fast-type motoneurons and their firing frequency accelerates. In contrast, slow-type motoneurons discharge immediately, and their firing frequency decreases at the beginning of the pulse. Here, we identify the i...

متن کامل

A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns

A two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (DCN) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. This conductance based model is a reduced version of KM-LIF model (Meng & Rinzel, 2010) which captures qualitative firing features of a...

متن کامل

Distribution of effective synaptic currents in cat triceps surae motoneurons. VI. Contralateral pyramidal tract.

We measured the effective synaptic currents (IN) produced by stimulating the contralateral pyramidal tract (PT) in triceps surae motoneurons of the cat. This is an oligosynaptic pathway in the cat that generates both excitation and inhibition in hindlimb motoneurons. We also determined the effect of the PT synaptic input on the discharge rate of some of the motoneurons by inducing repetitive fi...

متن کامل

Electrophysiological evidence for vasopressin V(1) receptors on neonatal motoneurons, premotor and other ventral horn neurons.

Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord. We sought to characterize their influence on neural excitability by using patch-clamp techniques to record AVP-induced responses from a population of motoneurons and interneurons in neonatal (5-18 days) rat spinal cord slices. Data were obtained from 58 thoracolumbar (...

متن کامل

The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons

Spinal motoneurons may display a variety of firing patterns including bistability between repetitive firing and quiescence and, more rarely, bistability between two firing states of different frequencies. It was suggested in the past that firing bistability required that the persistent L-type calcium current be segregated in distal dendrites, far away from the spike generating currents. However...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015