A critical evaluation of the prothrombin time for monitoring oral anticoagulant therapy.
نویسندگان
چکیده
The Quick prothrombin time is the most common clotting test performed, principally for monitoring oral anticoagulant therapy. The International Normalized Ratio (INR) for comparing patient results from prothrombin time measurements and the International Standardized Index (ISI) for achieving greater consistency of results using different thromboplastins have made it possible to compare the results of vitamin K antagonist drug therapy that was impossible before the introduction of the INR and ISI. However, INR values obtained from the same patient plasma sample using different thromboplastins are significantly different. This is so even when the thromboplastins have nearly the same ISI values. We suggest that investigation of patient-specific differences can provide a means by which the INR discrepancies can be identified and understood and thus lead to better methods for monitoring oral anticoagulant therapy.
منابع مشابه
Performance Evaluation of the Coag-Sense Prothrombin Time (PT)/INR Monitoring System
Oral anticoagulant therapy (OAT) using warfarin (Coumadin®) has surged in recent years due to an increased number of indications and its demonstrated effectiveness.1 The primary means of monitoring the response to warfarin is the Prothrombin Time (PT) test, which is measured in seconds.2,3 The increased use of OAT has led to the development of point-of-care (POC) portable monitoring devices des...
متن کاملPerformance Evaluation of the Coag-Sense Prothrombin Time (PT)/INR Monitoring System
Oral anticoagulant therapy (OAT) using warfarin (Coumadin®) has surged in recent years due to an increased number of indications and its demonstrated effectiveness.1 The primary means of monitoring the response to warfarin is the Prothrombin Time (PT) test, which is measured in seconds.2,3 The increased use of OAT has led to the development of point-of-care (POC) portable monitoring devices des...
متن کاملPerformance Evaluation of the Coag-Sense Prothrombin Time (PT)/INR Monitoring System
Oral anticoagulant therapy (OAT) using warfarin (Coumadin®) has surged in recent years due to an increased number of indications and its demonstrated effectiveness.1 The primary means of monitoring the response to warfarin is the Prothrombin Time (PT) test, which is measured in seconds.2,3 The increased use of OAT has led to the development of point-of-care (POC) portable monitoring devices des...
متن کاملInternational normalized ratio for prothrombin times in patients taking oral anticoagulants: critical difference and probability of significant change in consecutive measurements.
To determine when a change in serial measurements of prothrombin time in patients receiving oral anticoagulant therapy (ACT) is a statistically significant biological change necessitating dose adjustment, one must know the size of the "critical difference" in statistical terms (i.e., probabilities). In a cohort of 32 ACT patients at pharmacological steady-state, we studied the within-subject to...
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عنوان ژورنال:
- Pathophysiology of haemostasis and thrombosis
دوره 33 1 شماره
صفحات -
تاریخ انتشار 2003