Clinical trial of disodium cromoglycate in treatment of asthma in children.

of treatment and also later, when the patient is apparently adequately treated according to the prothrombin ratio. It appears that patients with venous lesions require more anticoagulant to produce the same partial thromboplastin clottingtime than do patients with arterial lesions, and this may have a bearing on relapses and further thromboses. Examination of results from 21 patients when they were bleeding suggests that the partial thromboplastin clotting-time may be a better test for the detection of potential bleeding and bruising after overtreatment, since it is sensitive to variations in concentration of factor IX, a factor which does not affect the prothrombin clottingtime. It is therefore proposed that the plasma partial thromboplastin clotting-time is the more valuable test for the control of oral anticoagulant treatment, and a suggested therapeutic range of values is given. I am grateful to my clinical colleagues for access to clinical case notes, to Dr. J. M. Naish for advice and encouragement, and to the technical staff of the haematology section for their enthusiastic assistance in this work.