Serum Tumor Necrosis Factor–α in Pre Eclampsia

Cy tok ines a re ma jo r con t r ibu to r s in pa thogenes i s o f p re eclampsia. Serum TNF-α was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean ar ter ia l b lood pressure . TNF-α was determined us ing sandwich ELISA techn ique . Se rum TNF-α l eve l in normal p regnan t f emales was 9 .3 ± 0 .56 pg /ml , whi le in p re -ec lampt ic p regnan t f emales i t was 67.66 ± 61.83 pg/ml. This increase TNF-α was highly significant (P<0.001). There was no significant changes in serum TNF-α with respect to maternal age, par i ty and mean ar ter ia l pressure in both normal and pre-eclamptic p regnanc i e s .