Synthesis and Anti-oxidant Activity of Some N- (anilinocarbonothioyl) Benzamide and Heterocyclic Based Thiourea Derivatives

A series of some novel n-(anilinocarbonothioyl) benzamide and heterocyclic based thiourea derivatives were synthesized and evaluated for anti-oxidant activity. The purity of the synthesized compounds were judged by their C, H and N analysis and the structure was analyzed on the basis of IR, NMR and Mass spectral data. The anti-oxidant activity of new compounds were determined on carbon tetrachloride challenged rats using Vit-E as a standard (Evion,E-merck). Among the compounds tested two compounds, A8 N-{[(4-hydroxyphenyl) amino] carbonothioyl} benzamide (% inhibition86.6), H10 N{[(4-methoxyphenyl) amino] carbonothioyl} benzamide (% inhibition 87.7) were the most active compounds in benzamide series. B3 N-(2-phenylethyl) piperidine-1-carbothioamide (% inhibition 84.4) and B4 N-(2-phenylethyl) morpholine-4carbothioamide (% inhibition 86.7) were the more active compounds in heterocycle based thioureas. As expected the compounds with phenolic hydroxyl and methoxy substituted compounds in benzamide series and in hereocylcle based thioureas morpholine and piperidine nucleus containing compounds showed more percentage protection than the other substituents containing compounds.