Intravenous injection of fluorescent iron-oxide nanoparticles for in vivo loading and tracking of monocytes to myocardial infarction by MRI and optical imaging
نویسندگان
چکیده
K. Montet-Abou, J-L. Daire, J-N. Hyacinthe, F. Mach, A. Petri-Fink, H. Hofmann, D. R. Morel, J-P. Vallee, and X. Montet Radiology, Geneva University Hospital and Faculty of Medicine, Geneva, Geneva, Switzerland, Cardiology, Geneva University Hospital, Geneva, Geneva, Switzerland, Laboratory of Powder Technology, EPFL, Lausanne, Vaud, Switzerland, Anesthesiological Investigation Unit, Geneva University Hospital, Geneva, Geneva, Switzerland
منابع مشابه
In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium.
AIMS To evaluate the feasibility of loading resting monocytes/macrophages by intravenous (i.v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic resonance imaging (MRI) and optical imaging. METHODS AND RESULTS Rats were injected with fluorescent iron oxide nanoparticles (10 mg/kg) (n...
متن کاملNoninvasive Stem Cell Labeling Using USPIO Technique and their Detection with MRI
Background: To date, several imaging techniques to track stem cells are used such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Bioluminescence imaging (BLI), fluorescence imaging, CT scan and magnetic resonance imaging (MRI). Although, overall sensitivity of MRI compared to SPECT and Bioluminescence techniques are lower, but due to high spatial reso...
متن کاملDual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction
PURPOSE Results for implantation efficiency and effective improvement of cardiac function in the field of mesenchymal stem cells (MSCs) are controversial. To attempt to clarify this debate, we utilized magnetic resonance imaging (MRI) and near-infrared optical imaging (OI) to explore the effects of different delivery modes of mesenchymal stem cells on cell retention time and cardiac function af...
متن کاملIn Vivo Tracing of Human Umbilical Cord Matrix Stem Cells Useing MRI
Purpose: Human umbilical cord matrix (UCM) (Wharton jelly) stem cells labeling are tracking by MRI. Materials and Methods: After 48 hours incubation with USPIO human umbilical cord matrix (UCM) stem cells were labeled with USPIO by the means of receptor-mediated endocytosis. Prussian blue staining and Atomic absorption spectroscopy were performed to identify and show the iron oxide nanoparticle...
متن کاملEffect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI
Objective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. In this study, we evaluate the dependency of hydrodynamic si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008