Asf1, a Loveseat for a Histone Couple
نویسندگان
چکیده
In this issue of Cell, English et al. present the first crystal structure of a histone chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides insights into how histone chaperones participate in nucleosome disassembly. It reveals that Asf1 physically blocks (H3/H4)(2) tetramer formation and that the C terminus of H4 undergoes a dramatic conformational change upon binding to Asf1.
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عنوان ژورنال:
- Cell
دوره 127 شماره
صفحات -
تاریخ انتشار 2006