OligoMix Microarray Synthesized Oligos for Targeted Sequencing

Next-generation DNA sequencing (NGS) has broad applications in both research and clinical diagnostics and has specifically become an important platform for identifying mutations and variants from clinical samples. Though NGS is capable of very high levels of coverage even on complex genomes, it is still advantageous to reduce the complexity of samples and sequence smaller targeted regions – in particular, when sample numbers are very high and the goal is detection of less prevalent or extremely rare mutations. Several academic and commercial groups have developed a variety of capture methods for enriching or selectively amplifying subsets of the genome for targeted sequencing.