7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione
نویسندگان
چکیده
There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(6)Cl(2)N(2)O(2). The conjugated four-ring system is essentially planar in each mol-ecule [maximum deviation = 0.089 (2) Å]. In the crystal, weak inter-molecular C-H⋯Cl, C-H⋯O and C-H⋯·N inter-actions help to stabilize the packing.
منابع مشابه
Antitrypanosomal activities of tryptanthrins.
New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent ...
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The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, mol-ecules form centrosymmetric π-overlapping dimers [inter-planar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O-H⋯N hydrogen bonds. C-H⋯O inter-actions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small ...
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In the crystal structure of the title compound, [Ag(NO(3))(C(15)H(8)N(2)O(2))(2)], tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione) and silver nitrate form a 2:1 complex. The silver ion is surrounded by two tryptanthrin ligands, each coordinating through the N atoms, with Ag-N bond lengths of 2.247 (3) and 2.264 (3) Å, and an anionic nitrate ligand coordinating through two O atoms, with Ag-O ...
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Microglia are the resident macrophages in the central nervous system (CNS) and play essential roles in neuronal homeostasis and neuroinflammatory pathologies. Recently, microglia have been shown to contribute decisively to neuropathologic processes after ischemic stroke. Furthermore, natural compounds have been reported to attenuate inflammation and pathologies associated with neuroinflammation...
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Treatment of 5,6-dimethoxy-2-(methylphenylcarbamoyl)-benzofuran-3carboxylic acid with PPA yielded 2,3-dimethoxy-7-methyl-7,12-dihydro-6H-[1]benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. The analogous 2-[(5,6-dimethoxybenzofuran-2-carbonyl)methylamino]benzoic acid was resistant to cyclization, whereas 2-[(6methoxybenzofuran-2-carbonyl)-amino]benzoic acid underwent cyclization to the corresponding...
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عنوان ژورنال:
دوره 66 شماره
صفحات -
تاریخ انتشار 2010