Brain Microdialysis in Knockout Mice : Drawbacks and Advantages to Study the Role of 5-ht1a and 5-ht1b Autoreceptors in the Mechanism of Action of Antidepressants
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چکیده
Abstract: From anesthetized rats in the 90s to conscious wild-type or knockout mice today, intracerebral in vivo microdialysis provided important information about the brain mechanism of action of psychotropic drugs such as antidepressants. The principle of microdialysis technique is based on the balance between the release of neurotransmitters (e.g., serotonin 5-HT, norepinephrine, dopamine) and re-uptake by selective transporters (e.g., SERT for 5-HT). Complementary to electrophysiology, this technique reflects
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تاریخ انتشار 2013