Targeting host calpain proteases decreases influenza A virus infection 1
نویسندگان
چکیده
1 Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France 4 2 INSERM U874, Paris, France 5 3 Institut Pasteur, Unité de Génétique Moléculaire des Virus ARN, Paris, France 6 4 School of public Health The University of Hong Kong, HongKong SAR, China 7 5 INSERM UMR-S1155, Paris, France 8 6 The HKU-Pasteur Research Pole, School of Public Health The University of Hong Kong, 9 HongKong SAR, China 10 7 Inserm U1100, Centre d’Etude des Pathologies Respiratoires, Tours, France 11 8 Université François Rabelais, Tours, France 12
منابع مشابه
Targeting host calpain proteases decreases influenza A virus infection.
Influenza A viruses (IAV) trigger contagious acute respiratory diseases. A better understanding of the molecular mechanisms of IAV pathogenesis and host immune responses is required for the development of more efficient treatments of severe influenza. Calpains are intracellular proteases that participate in diverse cellular responses, including inflammation. Here, we used in vitro and in vivo a...
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Calpains are calcium-dependent cysteine proteases that degrade cytoskeletal and cytoplasmic proteins. We have studied the role of calpains in the life cycle of human echovirus 1 (EV1). The calpain inhibitors, including calpeptin, calpain inhibitor 1, and calpain inhibitor 2 as well as calpain 1 and calpain 2 short interfering RNAs, completely blocked EV1 infection in the host cells. The effect ...
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تاریخ انتشار 2016